| |
|
A
Response to the NHMRC Position Statement 2002
"Dental
Amalgam - filling you in"
by Dr Robert Gammal BDS FACNEM(dent)
Dr Gammal is founder and past president of the Australasian
Society of Oral Medicine and Toxicology (ASOMAT), which was created
with the intent to bring to public and professional awareness the science
and the dangers associated with mercury from dental amalgam.
In August 1997 the
NHMRC withdrew its policy statement on the safety of dental amalgam.
At that time they held the view that Dental amalgam is an excellent
material for repairing decayed teeth and for many applications, it is
still preferable to the alternatives. The position statement was
withdrawn because the comments made by the NHMRC did not reflect the
content of the only reference which was used to justify their position.
At that stage the whole of Australia's policy on the safety of amalgam
was written on one A4 sheet of paper. It was not authored and
it was not a part of a larger document or report. In fact there
was no record of any committee who put it together.
Australia did not
have a policy statement for the five years that it took for the NHMRC
to arrive at their current position. During that time they created a working party to examine the
scientific research and reflect on the submissions (over 40) that had
been given to them. The working party made their report in February
1999. In that report they state Dental
amalgam is still a desirable direct restorative material from
a cost and longevity perspective and is the material of choice in certain
clinical situations where its properties are superior to alternative
materials. This is almost the exact statement used in the previous
position paper, but now we are supposed to think that amalgam is acceptable
because it is cheaper than the alternatives.
Incredibly, they also state that amalgam should not be used in children, pregnant women and
people with kidney diseases. Clearly the NHMRC believe that
mechanics and cost are of greater concern than the potential of being
poisoned by the third most toxic substance known to man. This
is in stark contrast to the position taken by other reputable governments
such as Sweden, Germany, Canada and California.
The working party also suggested that Australia should
conduct its own risk assessment on the dangers of mercury from dental
amalgam. One of the comments in the executive summary of this
Risk Assessment (No 8) is that removal of amalgam will allow a reduction
of the body burden of mercury to a level experienced prior to amalgam
placement.
The full NHMRC position statement can be found at http://www.nhmrc.gov.au
Think
About It:
The
only place that dental amalgam
can be stored safely and legally
is in
the mouth of a living person!
Everywhere
else it is TOXIC WASTE!
|
NHMRC Statements |
Robert Gammal
Comments |
What is the issue? |
|
1..... mercury,
a substance that at high levels can be harmful to human health. |
At
high levels mercury IS harmful to human health.
In fact at low levels mercury is harmful to human health. At low, CONTINUOUS exposure, mercury accumulates in the body. The brain and nervous
system are major areas of concern for the accumulation of mercury.
Mercury is Neurotoxic! In fact, ALL levels of mercury are harmfull to ALL living organisms!
The ATSDR list mercury as
the third most toxic substance known to man, after Arsenic and Lead.
Unlike Lead though, mercury is liquid at room temperature and vaporises atroom temperature and is thus more commonly bio- available than lead or arsenic. |
2.
Media stories and websites have fuelled these concern but they are sometimes
based on inaccurate information. |
2) Many websites
and media stories actually present accurate and scientifically referenced
information. Try out:
www.bcd.com.au
http://emporium.turnpike.net/P/PDHA/mercury/asr1.htm
http://www.hugnet.com/
http://www.algonet.se/~leif/yfVIM90a.html
http://www.altcorp.com/
http://www.algonet.se/~leif/AmFAQigr.html
It is a shame that the NHMRC tries to invalidate the mass of scientific research which disagrees with their position. |
3. Repeated
worldwide reviews of the scientific evidence have been unable to link
the use of dental amalgam directly with ill health1,2. |
3) Repeated World
Wide Reviews - How curious that we are not told the NHMRC
Working Party have acknowledged that no studies have been done which
test the proposition that amalgams are safe. So what are these
reviews looking at?
The references used here to support this statement
are reviews of the literature. Reviews Of The Literature Are
Just Reviews. They Are Not Scientific Studies.
It is incomprehensible that such an august body as the NHMRC should
rely on reports as references to their statements.
The references used:
1. ADA Council on Scientific Affairs.
Dental amalgam: update on safety concerns. Journal of the American Dental
Association. 1998 129:494-503.
It is well known that the AmDA is the greatest proponent
on the safety of amalgam. The Journal of the American Dental Association
rates as one of the least scientific journals in the world. [i] The American, like the Australian, Dental Association is
a trade organisation - it is NOT a scientific organisation.
How many people know the American Dental Association
owns patents on widely used amalgam formulations and yet at the
same time asserts the alleged safety of amalgams? Is this a conflict
of interest?
US Pat.4,018,600Waterstrat
April 1977
US Pat.
4,078,921Waterstrat March 14 1977
2. World Health Organization. Consensus
statement on dental amalgam, 7 March 1997. Geneva: WHO, 1999.
This was an unofficial report from a subcommittee
of dental personnel. The World Health Organization have clearly stated
that it should not be used to suggest that it was their official position, and have in fact distanced themselves from this supposed consensus statement.
It is curious that NHMRC is willing to cite an unofficial
document yet ignores an official one (World Health Organization Criteria
118, published in 1991 with full ownership by the WHO), which
states clearly that dental amalgam is the greatest source of
mercury to the general population - in the order of 3 - 17 times
greater than all other sources combined (including fish and other sea
food).
In Criteria 118 they also stated clearly that for
mercury vapour a specific 'no-observed-effects-level' (NOEL) cannot be
established, meaning that NO level of mercury vapour that
can be considered harmless has been found. WHO also stated
"There are at present no suitable indicator media that will reflect
concentrations of inorganic mercury in the critical organs, the brain
or kidneys, under different exposure situations".
For further insight into the lack of research on the
safety of amalgams see the comments made by Dr Boyd Haley (Prof Chemistry,
University of Kentucky):
Dr. Haley Rebuts the American Dental Association Position
on Mercury Amalgam Safety
23 May 2001
The Honorable Dan Burton Chairman Committee on Government
Reform U.S. House of Representatives Washington, D.C.
Issued late in 1997, the FDI World Dental Federation
and the World Health Organization consensus statement on dental amalgam
stated "No controlled studies have been published demonstrating
systemic adverse effects from amalgam restorations. My first comment
would be to question "who staffed these committees and what percentage
were connected to the ADA though the NIDCR or the FDA dental materials
branch or other relationships?" We appear to have the foxes guarding
the henhouse! Then I would again point out that "absence of proof
is not proof of absence". I would then ask have any controlled
studies been done and if not, why not? If the ADA dentists insist on
placing amalgams in the mouth, are they not required to show it is safe,
not the other way around? Should not the ADA and others concerned push
to require the FDA to prove amalgams are safe instead of totally ducking
this issue. Go to the FDA dental materials web-site and try to find
any evaluation of amalgam safety---you will not succeed. The dental
branch of the FDA refuses to do a safety study on amalgams and this
is shame on our government.
Dr Haley's website is http://www.altcorp.com
On 9 August 2002, The Court of Appeal, in California,
issued a ruling that should have a dramatic impact on the dental amalgam
mercury controversy. [Consumer Cause v. Smilecare, 91 Cal. App.
4th 454 (200 1), B 147727] Bio Probe
Vol 19 Issue 2 March 2003, make the following points.
Previously, the defenders
of amalgam mercury have always been successful with their position that
the safety of the material, although it is known to be a strong poison,
has been established by 150 years of use and the consensus opinions
of an "alphabet soup" of committees.
The second important point
is the insistence of the Court and the Attorney General that determination
of the issue be decided by formal and proper "Risk Assessment."
Previously, defendants have relied on the contention that it has not
been proven that dental amalgam mercury causes any one of several 'named'
diseases, such as Multiple Sclerosis (MS) or Alzheimer's Disease (AD).
Mercury is a poison, similar to lead or arsenic. Nobody declares that
lead or arsenic are not poisonous because it has not been proven that
they cause MS or AD! Human risk from exposures to lead or arsenic are
determined by Risk Assessment. Exposure to mercury should be addressed
the same way. The Court agreed.
The end result was that on 7 January 2003, the Superior
Court in San Francisco approved the final language for warnings on dental
amalgam mercury that are required under California's Proposition 65:
"NOTICE
TO PATIENTS. PROPOSITION 65:
Warning
on dental amalgam, used in many dental fillings, causes exposure to
mercury, a chemical known to the state of California to cause birth
defects or other reproductive harm. |
Can mercury from fillings
enter the body? |
|
1.Very small amounts of mercury
are released from the surface of dental amalgam fillings, mainly as
mercury vapour. |
1) There is no known level of mercury vapour which is regarded as SAFE
(a no-observable-effects-level [NOEL] has never been demonstrated). To date there is not one agency in the world including the USEPA, FDA,
and ATSDR nor the NHMRC who have shown a safe minimum level of mercury
vapour.
The use of the words "very small amounts" implies a harmless nonexistant level. Health Canada attacked the Canadian Dental Association for making similar comments:
Canadian Dental Association:
Q. Is the mercury which is released from fillings absorbed into the body?
A. Yes, but in extremely small amounts, i.e. in MILLIONTHS of a gram (this is very small amount, 0.000001 grams.)
Dr Tobin's Response:
"This answer is rather condescending and insulting to the intelligence of readers. By emphasizing only how small a microgram is it implies that a microgram of toxic material could not be harmful. What is significant is not now many zeroes there are in a microgram, but how many micrograms of mercury are released by and compared to the number of micrograms required to cause illness. The fact is that a level of only one hundred millionths of a gram (only 0.0001 gram) of mercury per gram of Creatinine in urine is considered to indicate clinical mercury poisoning."
Mercury is released continuously from
amalgam, mainly in the form of mercury vapour, which is considered one
of the most toxic and most bioavailable forms. 80% of inhaled
vapour is absorbed through the lungs. [ii]
Early symptoms of low-level mercury poisoning are characterised by
sub-clinical (no clinical symptoms are visible) neurological (effecting
the nervous system) symptoms. It is nonsense to think the dental
profession does not know this. Even the New York State Dental Journal
(1979) state:
|
2 .....In this way, some mercury
can reach the rest of the body and accumulate in certain organs, particularly
the kidneys. |
2) Mercury is a cumulative toxin.
It accumulates and stays in the body. Although highest levels
are found in the kidneys, the other main organ for the accumulation
of mercury is the brain. Mercury readily crosses the blood brain
barrier and remains in the brain. Mercury is neurotoxic.
Its most widely known damage is thus in the central and peripheral nervous
systems. Alzheimer's Disease and many other serious neurological
diseases are strongly related to mercurylxii .
The mention of mad hatters in the NHMRC article (point 3 of what are
the health effects?) must surely indicate that this information
is known to the NHMRC. |
3. However, the mercury levels
involved are very low, so the amount of mercury absorbed into the body
is very small. |
3) This statement ignores the toxicity
of mercury. For example a speck of plutonium is small but it will kill
within a few days. To say that mercury vapour levels are low without
taking into account its toxicity is, at best, misleading and at worst,
deceiving.
Research has shown that over 80% of the inhaled mercury vapour
is absorbed into the body via the lungs. Where is the NHMRC's evidence that small
levels of mercury vapour are safe when ATSDR lists mercury vapour as
one of the most toxic substances known to man? Interestingly, Canada
Health (the Canadian equivalent of the NHMRC) have fully endorsed the
1995 Richardson report [iii] which clearly indicates that
1 Filling in Toddlers;
1 Filling in Children;
3 Fillings in Teens;
4 Fillings in Adults and Seniors
provides the equivalent amount of mercury which the
USEPA has set as its Tolerable Daily Intake-TDI . More fillings
will of course result in exceeding these TDI levels.
Intra-oral mercury vapour levels are reported in the order of
200 times greater than that accepted by the ATSDR .
The ATSDR MRL for inhalation exposure to metallic mercury vapour is
2x105 mg Hg/m3 ( 0.02 mcg Hg/m3) and
the MRL for chronic inhalation exposure to metallic mercury vapour is
1.4x105 mg Hg/m3 (0.014 mcg Hg/m3).
These standards are both well below (by more than 5000 times) exposure
levels to mercury vapour that have been well documented to emanate from
amalgam dental fillings, even in the absence of stimulation. [iv]
Mercury vapour concentrations in the mouth of someone with amalgam
fillings have been shown to be between 30 and 150mcg/m3. [v] , [vi] , [vii] , [viii] , [ix] , [x] , [xi] , [xii] , [xiii] |
4. The amount of mercury released
from fillings is greatest when fillings are being inserted or removed. |
4)
The amount released during insertion or removal is significant and although
the increase in mercury exposure is only transient, it can be more than
enough to top the balance of people who are already sensitized and poisoned
by mercury. This is really an added insult to the already overloaded
patient because mercury is released continuously from amalgam for the
ENTIRE LIFE of the amalgam.
For this reason it is critical that correct
removal procedures be followed and in fact that no amalgam should ever
be placed in teeth. Apart from insertion and removal, eating, chewing,
grinding, and drinking hot drinks will cause an increased release of
mercury from amalgam. After such stimulation the levels remain
elevated for up to 90 minutes. [xiv] , [xv] |
What is dental amalgam? |
|
1. ....generally made up of
mercury, silver and tin with small amounts of copper and zinc. |
1) Even here the NHMRC cannot openly
acknowledge that the bulk of a dental amalgam,
is mercury, (about 50% of it in fact), with the rest being made up of all the other materials.
Half of every amalgam filling is mercury, which continually leaks out
and vaporizes over the ENTIRE LIFE of a filling. The ONLY way not to
be exposed from this source is to not have amalgam fillings. Research
has clearly shown that the mercury levels in people without amalgams,
or who have had their amalgams removed, are significantly lower than
those people WITH amalgams in their mouths.
WHO in 1991 stated clearly that dental amalgam is the greatest single source of dietary mercury to the general population. |
2. The use of amalgam for
dental work is declining..... |
2) ANY use of amalgams represents a
deliberate use of a material which is known to be the major source
of mercury vapour exposure in human beings. Current dental materials
technology is such that there is not one use for amalgams which cannot
be satisfied by the clinically competent use of other and better alternatives.
In 2003, the Swedish Government stated that;
"With reference to the fact that mercury is a multipotent toxin with
effects on several levels of the biochemical dynamics of the cell,
amalgam must be considered to be an unsuitable material for dental
restoration. This is especially true since fully adequate and less
toxic alternatives are available."
|
What are the health effects? |
|
1. High levels of mercury
are harmful to human health. ......, producing signs such as mood swings,
memory loss and development of tremors. |
1)
This statement is factually wrong because it is, in fact, low levels
of mercury vapour which will produce signs
such as mood swings, memory loss and development of tremors. These
are the early symptoms of low-level long term mercury poisoning - NOT the late ones, and they are not the symptoms seen in high level
mercury poisoning. High level poisoning is accompanied with rapid
kidney failure. |
2. In rare cases, a person
may be allergic to mercury. |
2)
Peer reviewed published research has reported allergy levels of 5%‑8% (Rudner,) 27% (Djerrasi &
Berova), 2%‑10.8 % (White & Brandt), 31%, 27%, 32%, 39% (Miller et al), 11.3% (Brun), 9.6
% (Nebenfuher et al), 13% (Sato et al) [xvi] , [xvii] , [xviii] , [xix] , [xx] , [xxi]
These are NOT small figures. Assuming that only half of the Australian
population have amalgam fillings we could conservatively expect that
between 475,000 and 3,705,000 people are sick as a direct
result of allergy to amalgam.
In the past the ADA have made allegations that less than one percent
of the population is allergic to mercury. They have never been
able to substantiate this claim with any references.
The AMerican Dental Association have now reviewed this figure and claim that 3% of the population is 'allergic' to amalgam.
Even Caulk Co, the manufacturers
of the Dispersalloy brand of amalgam, warn: "Allergic
reactions that may occur in previously exposed persons include dermatitis,
encephalitis, and death.
Unfortunately true allergy
is only one of the immune effects of mercury Ð there are many others. [xxii] , [xxiii] |
3. The phrase 'mad as a hatter'
came about because the hat makers of the 19th century were exposed to
high levels of mercury,....... |
3) Dental personnel are exposed to exceptionally high levels of mercury vapour. Evidence exists which shows significant
health problems in dentists and dental nurses. Dentists have one
of the highest suicide rates of any profession. [xxiv] Dentists also have twice the rate of Glioblastoma (a type of brain cancer)
than the rest of the population. [xxv] The authors of this study also state In the group of dental personnel,
the effect of their own amalgam fillings on mercury concentrations....was
as important as their occupational exposure to mercury.
Dentists also show evidence of subtle pre-clinical changes in behaviour
associated with mercury exposure:
functions related to complex attention, psychomotor task, mood. [xxvi] , [xxvii]
Shapiro, et al. and Ship II, et al. reported the relation
between cumulative exposure to mercury and chronic health impairment.
Of 298 dentists, 30% of the high mercury dentists had polyneuropathies.
No polyneuropathies were detected in the control group. The high mercury
group had mild visuographic dysfunction; they also had more symptom-
distress than did the control group. [xxviii]
There are many studies demonstrating that female dental personnel suffer
dramatically from exposure to mercury in the dental environment. One
such states:
Female dentists had a higher rate of spontaneous
abortions then a control of female medical personnel or the rest of
the population.
The Peri-Natal Mortality Rate for the female
dentists was significantly higher than for the rest of the population
- 19.5 / 1000 as compared to 7.5 / 1000 [xxix]
Unfortunately the problem does not stop
with the dental nurse but is passed on to the offspring:
"rates of spontaneous abortion or non-congenital
abnormalities in children during this period, were higher in respondents
exposed to high levels of mercury in the dental environment than those
exposed to low levels". This is published in the Journal of the
American Dental Association Vol 122 August 1991. It was written
by Irwin Mandel DDS., Assoc. Dean for Research School of Dental and
Oral Surgery Colombia University New York.
Another
study reported a high frequency of adverse events of pregnancy among
dental staff and learning deficit disorders in children of mothers having
been exposed to mercury. [xxx]
The United States Environmental Protection
Agency stated:
Women chronically exposed to mercury vapour
experienced increased frequencies of menstrual disturbances and spontaneous
abortions.
A high mortality rate was observed among infants
born to women who displayed symptoms of mercury poisoning. [xxxi] |
Is dental amalgam likely
to affect me? |
|
1. Different people have different
tolerances to chemicals in the environment; however, in the opinion
of the World Health Organization the levels of mercury exposure from
amalgam fillings do not affect general health. |
1) There has never been a level of mercury
exposure set which is regarded as safe. A NOEL for mercury does not
exist! What is their reference for this comment? Authoritative
bodies such as the American NIH and even the NHMRC inquiry acknowledged
that there were no studies which even looked at the issue. |
2. ..... There is no reliable
evidence that people with such fillings have a greater risk of ill health
than people without amalgam. |
2) The Absence of Evidence is NOT Evidence of Absence. This is
particularly pertinent when, as mentioned above, it has been acknowledged
that virtually no studies have been done which even look at this issue. |
3. A very small number of
people may experience local side effects due to an allergic reaction
to dental amalgam, causing irritation in the tissues surrounding the
tooth. However these local effects appear quickly, and can be
recognised and treated. |
3) The chances of any dentist recognising
mercury allergy if it presented are extremely low. No training is given
in this area, nor is it written about or discussed. Again, no reference
is given to support this assertion. The fact is that any problems experienced
are likely to be presented to a medical practitioner who is also very
unlikely to recognise it as a low level mercury toxicity problem.
Local reactions DO NOT necessarily appear quickly and the only 'treatment' is to remove the caue. ie. remove the amalgam.
Local reactions are NOT the only affect on the immune system. See www.melisa.org to gain an understanding of how mercury and other heavy metals can instigate a variety of auto immune diseases.
The medical profession, as well as
the dental profession, are also almost certainly unaware that mercury
from amalgam has been shown to cause an increase in mercury-resistant
and antibiotic-resistant bacteria in the human body [xxxii] . Antibiotic resistance
has become a major medical public health concern and limits the effectiveness
of antimicrobials. The authors of the research which showed this
noted that since dental amalgam is a greater source of mercury exposure
for humans than any other non-occupational source (including food),
it is likely that dental amalgam mercury is a selective agent which
increases the prevalence of plasmid-associated mercury and antibiotic
resistances in the oral and intestinal bacteria of humans.
Caulk Co., the manufacturers of Dispersalloy, state in the MSDS for
this product:
Exposure
to mercury may cause irritation to skin, eyes, respiratory tract and
mucous membrane. In individual cases, hypersensitivity reactions, allergies,
or electrochemically caused local reactions have been observed. Due
to electrochemical processes, the lichen planus of the mucosa may develop.
Mercury may also be a skin sensitizer, pulmonary sensitizer, nephrotoxin
and neurotoxin......Allergic
reactions that may occur in previously exposed persons include dermatitis,
encephalitis, and death. |
Putting the issue in perspective |
|
1. Of the mercury found in
the body, less is likely to have come from dental amalgam than from
other sources. |
1) This statement is blatantly false! It has neither
a reference nor any credibility.
WHO Criteria 118 - Environmental Mercury 1991
Between 3-17 times more mercury is absorbed from dental amalgam
as compared to all other sources combined including seafood.
ATSDR Elemental Mercury and
Inorganic Mercury Compounds: Human Health Aspects (No 50) - Exposure to elemental mercury by the general population
and in occupational settings is primarily through inhaling mercury vapours/fumes.
Dental amalgam constitutes a potentially
significant source of exposure to elemental mercury, with estimates
of daily intake from amalgam restorations ranging from 1 to 27 µg/day....
This ATSDR quote is from the very document used
by the NHMRC in this pamphlet - Reference No 3.
Professor Drasch, Professor of Forensic
Medicine at Munich, says: Hg found in tissues of individuals
with amalgam fillings derive mainly from these fillings and not from
other theoretically possible sources.xliii (Hg is the Scientific notation for mercury.) |
2. Mercury is present at low
levels in our environment as a naturally occurring element in air, water
and food. |
|
3. Mercury in food, particularly
in fish, is often in a form that can be easily absorbed by the body
(in contrast to the mercury in dental amalgam). |
3) There is no doubt
that organic forms of mercury are readily absorbed. This has been
known for years. It is amazing that the NHMRC suggest that elemental
mercury (that which comes from amalgam) is not readily absorbed, particularly
when they are referencing their position with the ATSDR paper which
clearly states the opposite of what they are saying:
For elemental mercury, the main route of exposure is by inhalation,
and 80% of inhaled mercury is retained......Elemental mercury is lipid soluble and easily
penetrates biological membranes, including the bloodÐbrain barrier.
Metabolism of mercury compounds to other forms of mercury can occur
within the tissues of the body.
It has been known for some time that mercury
can be converted to organic mercury in the intestinal tract of human
beings. [xxxiii] , [xxxiv] More recently a study
has been published which demonstrates that elemental mercury from dental
amalgam can be converted in the mouth to organic mercury. The
authors conclude:
Our results are compatible with the
hypothesis that amalgam fillings may be a continuous source of organic
mercury, which is more toxic than inorganic mercury, and almost completely
absorbed by the human intestine. [xxxv]
|
4. The use of dental amalgam
has been recommended to be phased out in Scandinavia and other parts
of Europe, once satisfactory alternative materials become available.
The reason for this was mainly concern over the release of toxic substances
into the environment rather than concern about potential health effects
for the individual. |
4) This statement borders on the incredible
suggesting that human beings are in some way separate from the environment.
Especially in terms of mercury derived from dental amalgam, it is the
human being who is the first in line of the environment. See reference xxxix in the next section.
Why is it that the environment should be protected if not for the
sake of preserving life and health of all sentient beings who live on
this planet?
The truth is that mercury from dental amalgam is a MAJOR source of mercury to the environment. |
Mercury and the environment |
|
1 Human activities since the
start of the industrial age (eg mining, burning of fossil fuels and
solid waste incineration) have resulted in additional release of mercury
into the environment3..... As mercury moves up the
food chain it becomes more concentrated. |
1) This is the only place in the pamphlet
that cites the ATSDR document. The rest of the ATSDR document
seems to have been ignored.
It has been known for many years that crematoria release huge amounts
of mercury into the environment. Estimates indicate that each
chimney releases about 11Kg mercury per year. [xxxvi] , [xxxvii] , [xxxviii]
If the NHMRC are so concerned about the environment why have they still
not imposed a requirement that all crematoria use mercury collection
devices. Surely this must be regarded as industrial exposure with
environmental and health risks.
Mercury released from amalgam in living people is also a major concern:
These results demonstrate
that humans, especially in populated areas, can be a significant source
of mercury pollutants. As a consequence of mercury release, bacteria
may acquire mercury resistance, as well as resistance to other microbial
agents. [xxxix]
|
2. Dental amalgam adds to
the level of mercury in the environment when wastes from dental offices
are not disposed of properly, and through cremation, which vapourises
the mercury in amalgam fillings (although mercury vapour collectors
are now often used at crematoriums to prevent this) |
2) Dental offices are significant
contributors of mercury into the environment. Why has the NHMRC
not set guidelines for the compulsory use of mercury separators in dental
surgeries? It is a shame that they forgot to mention that once the human is no longer alive the amalgam in the mouth of that dead human is a serious TOXIC WASTE. |
Pregnancy |
|
1 During pregnancy,
placement of new amalgam fillings or removal of old ones is not recommended,
because the level of mercury in the blood tends to rise briefly in these
situations. The mercury can cross the placenta and enter the bloodstream
of the fetus4,5. |
1) There is no doubt that placement
and removal of amalgam produce high levels of mercury but low levels
of mercury are released from amalgam continuously.
The levels of mercury in the foetus and new born are directly proportional
to the number of amalgams in the mother s mouth.
These results
came from autopsy studies on foetus and new born children many of whom
died from Sudden Infant Death Syndrome. [xl] , [xli]
Women of child bearing age
and younger should not have amalgam in their mouths!
Studies on sheep have shown that the mercury is stored in all parts
of the body of the foetus including the developing central nervous system
and pituitary gland. [xlii] The authors state: "We conclude
that Hg released from dental amalgam tooth fillings will begin to selectively
accumulate in maternal and fetal tissues soon after amalgam placement.
.... Amalgam restorations are a source of continuous Hg exposure to
both mother and fetus. In view of the experimental evidence presented
herein, continued employment of dental amalgam as a tooth restorative
material in pregnant women and children should be reconsidered."
Another study states:
... inorganic mercury found in tissues of people with amalgam fillings, derive mainly from these fillings and not from other theoretically
possible sources. [xliii] |
2 There is no scientific
evidence of any link between amalgam use and birth defects or stillbirths.
However, current thinking is that it is better to avoid dental work
involving amalgam when possible during pregnancy, unless the effects
of avoiding treatment could cause greater problems, eg the loss of a
natural tooth. |
2) This statement is sadly incorrect
and misleading. [xliv] , [xlv] , [xlvi] , [xlvii] , [xlviii] , [xlix] , [l] , [li] It is clear that mercury
is embryotoxic, teratogenic and mutagenic. The dates of these
references make it abundantly clear that this information has been around
for a very long time.
Lets also look again at what Caulk Co say about their amalgam product
side effects:
The use of amalgam is contraindicated:
- In proximal or occlusal contact to dissimilar metal restorations.
- In patients with severe renal deficiency.
- In patients with known allergies to amalgam.
- For retrograde or endodontic filling.
- As a filling material for cast crown.
- In children 6 and under.
- In expectant mothers.
Caulk Co go on to say:
Intrauterine exposure may result in tremors and involuntary movements
in the infants. Mercury is excreted in breast milk. Paternal reproductive
effects and effects on fertility have been reported in male rats following
repeated inhalation exposures.
Ivoclar (another amalgam manufacturer) go further and contraindicate
the use of amalgam in pregnant and lactating women.
More recent studies indicate that:
Mercury vapor released from the amalgam
fillings in pregnant rats was distributed to maternal and fetal organs
in dose‑dependent amounts of the amalgam fillings. [lii]
In studies on animal offspring in utero
exposed to mercury vapor, behavioral changes, such as radial arm maze,
morris maze and lever‑press durations, are observed when the levels
of mercury vapor exceed the threshold limit value. [liii] |
Breastfeeding |
|
Women who are breastfeeding
should also avoid having amalgam fillings inserted or removed, because
mercury can be passed to the baby through breast milk. Of course, there
are some situations during pregnancy or breastfeeding where dental work
using amalgam might be necessary, and there is no scientific evidence
that this will cause harm. |
Again it is well known that mercury
in all forms will be carried through the breast milk to the developing
infant.
The higher Hg burden of infants' tissues from mothers with dental amalgam,
as reported previously, must be explained (1) by a prenatal transfer
of Hg from the mother's fillings through the placenta to the fetus,
followed by a redistribution of this Hg in the body of the newborn,
and ( 2) an additional burden via breast milk. [liv]
Of course there is a high level of exposure to mercury during placement
or removal of amalgam BUT there is also a high level of mercury in the
breast milk directly from the amalgam which is already present in the mother's mouth.
It would thus be advisable for all women of child bearing age and younger
not to have amalgam in their mouths to start with.
Intrauterine exposure may result in tremors and involuntary movements
in the infants. Mercury is excreted in breast milk. [lv] |
Children |
|
|
Amalgam is
now generally avoided for filling children's teeth. Growing children
tend to be more sensitive to the effects of exposure to any chemical
substance in their environment. Several of the new tooth‑coloured
materials are suitable for use where cavities are small, as they often
are in children. |
Amalgam is still being used in many,
if not most, school dental services throughout Australia.
Amalgam is still used by the majority of paediatric dentists. Amalgam
restoration of deciduous (milk) teeth is still being taught at most
university dental schools.
Amalgam is routinely placed in children's teeth in dental surgeries
throughout Australia partly because the dental authorities still promote
the false notion that there is no suitable alternative for large cavities.
Suitable alternatives have been available for many years! Why continue
exposing the most sensitive members of the population to one of
the most toxic substances known to man? |
Kidney disease |
|
Because high levels of mercury
exposure may affect the kidneys, people with kidney disease may be more
concerned than others to minimise exposure to mercury. |
As
mentioned earlier, High Level Mercury Poisoning is accompanied
with Kidney Failure.
Low levels of mercury will
have a dramatic effect on kidney filtration function. Severe Renal
Dysfunction is cited by Caulk Co. as a contraindication (ie not recommended).
Ivoclar go much further in their contraindications! They say their
amalgam is not only contraindicated for patients with severe renal deficiency
but for all patients suffering from a reduced kidney function.
Sheep studies have found a 50% reduction in kidney filtration rates
after the placement of dental amalgam fillings. [lvi] |
| |
No reference is made in the NHMRC pamphlet
about the effects of mercury in relation to:
Health effects on dental
personnel [lvii] , [lviii] , [lix] , [lx] , [lxi]
Central nervous system
- so numerous it would fill pages just to give all references
Mercury causing identical
changes in the brain as is found in the brain of Alzheimer's Disease [lxii]
Intelligence in children [lxiii]
Periodontal disease [lxiv]
Immune function [lxv] , [lxvi]
Auto Immune Diseases [lxvii] , [lxviii] , [lxix]
Endocrine function [lxx] |
Should amalgam fillings
be replaced? |
|
1 There is no
support in the scientific literature for the idea that the mercury released
from amalgam fillings is harmful to an individual's health. |
1) Mercury from dental amalgam is a cumulative poison. The longer you are exposed to it, the more will accumulate in your body! Mercury may not cause a specific disease, but it does cause mercury poisoning, which IS characterised in the largest array of diseases and syndromes known.
Mercury released from dental
amalgam fillings is mainly in the form of vapour and as mentioned previously,
80% of inhaled mercury enters the blood and the body.
Again from
the ATSDR document (reference 3 of the NHMRC pamphlet) available at http://www.who.int/pcs/cicad/summaries/cicad_50.html:
"Neurological and behavioural disorders
in humans have been observed following inhalation of elemental mercury
vapour, ingestion or dermal application of inorganic mercury-containing
medicinal products, such as teething powders, ointments, and laxatives,
and ingestion of contaminated food. A broad range of symptoms has been
reported, and these symptoms are qualitatively similar, irrespective
of the mercury compound to which one is exposed. Specific neurotoxic
symptoms include tremors, emotional lability, insomnia, memory loss,
neuromuscular changes, headaches, polyneuropathy, and performance deficits
in tests of cognitive and motor function.
Although improvement in most neurological dysfunctions has been observed
upon removal of persons from the source of exposure, some changes may
be irreversible.
Acrodynia and photophobia have been reported in children exposed to
excessive levels of metallic mercury vapours and/or inorganic mercury
compounds. As with many effects, there is great variability in the susceptibility
of humans to the neurotoxic effects of mercury.
The primary effect of long-term oral
exposure to low amounts of inorganic mercury compounds is renal damage.
Inorganic forms of mercury have also been associated with immunological
effects in both humans and susceptible strains of laboratory rodents,
and an antibody-mediated nephrotic syndrome has been demonstrated
through a variety of exposure scenarios." [lxxi]
|
2 There is no scientific
evidence showing that general symptoms are relieved by the removal of
amalgam restorations 2 |
2) The NHMRC statement is clearly incorrect.
There is ample evidence which suggests that removing dental amalgam
will reduce the body burden of mercury to pre-amalgam levels.
In fact as part of creating their 2002 document the NHMRC called for their own new risk assessment ot be done. It is clearly stated in section 8 of the executive summary
of the Risk Assessment conducted on behalf of the NHMRC.
“Amalgam removal has been shown to be effective in reducing mercury levels to the levels of those in people without amalgam fillings.”
The first step
to detoxify anyone is to first remove them from the source of the poison! |
3. In fact, there are disadvantages
to having amalgam fillings replaced ‑ replacement can be expensive;
it almost always causes more of the natural tooth to be lost; and, mercury
levels in the body rise immediately after amalgam fillings are replaced
due to the manipulation of the amalgam. Alternative materials such as
gold, ceramics or composite resins (plastics) require more of the tooth
to be removed. Composite resins are also more prone to wear so they
usually do not last as long as amalgam fillings. |
3) It seems that the NHMRC need to take
further advice on the material aspects of dental amalgam.
Dr. Harold Loe, the Director of the National Institute of Dental Research
(NIDR), stated in the September, 1993 edition of "Dental
Products Report":
"That first filling is a critical step in the life of a tooth.
Using amalgam for the first filling requires removing a lot of the tooth
substance, not only diseased tooth substance but healthy tooth substance
as well. So, in making the undercut you sacrifice a lot, and this results
in a weakened tooth. The next thing you know the tooth breaks off, and
you need a crown. Then you need to repair the crown...and so it continues
to the stage where there is no more to repair and you pull the tooth.
With the first filling you should do something that can either restore
the tooth or retain more healthy tooth substance. Use new materials-composites
or materials you can bond to the surface without undercuts. You can
do this with little removal of the tooth substance so that the core
of the tooth is still there." |
4 If you decide to have
amalgam fillings replaced, your exposure to mercury can be reduced by
using a rubber shielding device called a 'dental dam' and having extra
suction during the removal. Dentists can also cut away, rather than
drill out the amalgam filling, to help reduce exposure to mercury. Check
that your dentist uses these measures before undertaking dental amalgam
procedures. |
4) If a rubber dam should be used during
removal, why does the NHMRC not recommend it be used during placement
when it says that mercury exposure is highest during removal AND placement?
How does the NHMRC recommend that patients protect themselves from the
continuing mercury vapour exposure which occurs 24 hours per day, 7
days per week, Or from the spikes in mercury vapour release, which can
last up to 90 minutes, whenever someone eats or has a hot drink?
Amalgam removal protocols have been in place for many years but are routinely ignored by the dental profession. I would like to know what the NHMRC considers to be sufficient protection. Why does the NHMRC NOT advise dentists to use similar protective measures when they work daily with amalgam? |
5 The decision
to replace amalgam fillings is an individual one, and you should make
it in consultation with your dentist. If you feel that you need further
information after reading this leaflet and talking to your dentist,
it may be a good idea to seek a second opinion. |
5) All patients have the right
to be fully informed about any material or device which is to be implanted
into their bodies. Without full information it is not possible
to make informed decisions. In this regard the advice given in
this statement by the NHMRC is misleading rather than informative as
the NHMRC does not cite any alternate sources of information.
Most dentists are unaware of the dangers that they place themselves, their staff and their patients in when using amalgam. Most dentists are themselves seriously affected by the mercury from amalgam. These effects include an impairment of cognitive understanding. It is like setting the fox to gaurd the chickens. |
Further information |
|
Further information on the
effects of amalgam fillings and their benefits and disadvantages can
be found on the World Health Organization website http://www.who.int/ncd/orh |
Also see the submission presented to
the NHMRC by ASOMAT 1998 (www.asomat.org)
Instead of the URL presented here, I would suggest that you just go to the home page of the WHO and start your own search on amalgam and mercury.
Further information is available at many web sites and from many organisations.
Many are listed on the 'links' page.
|
Source References |
|
1.
ADA Council on Scientific Affairs. Dental amalgam: update on safety
concerns. journal of the American Dental Association. 1998 129:494-503.
2. World Health Organization.
Consensus statement on dental amalgam, 7 March 1997. Geneva: WHO, 1999.
3. ATSDR. Toxicological
Profile for Mercury. U.S. Department of Health & Human Services,
1999.
4. Committee on Toxicity
of Chemicals in Food, Consumer Products and the Environment. Statement
on the Toxicity of Dental Amalgam. Department of Health, United Kingdom,
December 1997.
5. Ad Hoc Working Group.
Dental Amalgam. A report with reference to the Medical Devices Directive
93/42/EEC. European Commission, 1998. |
No
3 ATSDR is the only reference used here which has any scientific
credibility. As demonstrated above, this one reference alone
disagrees with many of the statements made by the NHMRC.
The Australian and the American Dental Associations are NOT scientific
organisations but trade organisations. The objectivity
of the publications of the dental associations on this issue is, unfortunately,
quite suspect.
The World Health Organization Consensus
statement on dental amalgam, 7 March 1997, is without an author and
has never been endorsed by the WHO. In fact it is a document written
in conjunction with the FDI - another dental trade organisation. In
the words of Dr Boyd Haley:
"Issued late in 1997, the FDI World Dental Federation and the
World Health Organization consensus statement on dental amalgam stated
"No controlled studies have been published demonstrating systemic
adverse effects from amalgam restorations." My first comment would
be to question "who staffed these committees and what percentage
were connected to the ADA though the NIDCR or the FDA dental materials
branch or other relationships?" We appear to have the foxes guarding
the henhouse! Then I would again point out that "absence of proof
is not proof of absence". I would then ask have any controlled
studies been done and if not, why not?
Interestingly, no mention is made of the position statement of Canada
Health 1996:
Dentists should provide their patients
with sufficient information to make an informed choice regarding the
material used to fill their teeth, including information on the risks
and benefits of the material and suitable alternatives.
|
The advantages and disadvantages
of dental amalgam |
|
In many respects, amalgam
is an excellent filling material, because:
It is reasonably priced.
It is highly durable - apart from gold and some of the new ceramics, amalgam
is the best material for teeth that are subject to considerable force
during chewing and therefore a lot of wear (such as molars). Any replacement
weakens the natural tooth that is being filled, so the longer a filling
lasts, the better.
It is pliable when first mixed and can be moulded into a tooth cavity - reducing
the amount of natural tooth that needs to be removed in order to fit
the filling. |
The reality is that many dentists, particularly
those who no longer use amalgams, would disagree completely with that
statement. The newest composite resins have properties which make them
a more than adequate alternative, and in a number of respects a much
better alternative, especially in the area of minimal tooth preparation
and bonding to undermined tooth structure. Evidence exists that teeth
can be cracked by amalgams, presumably due to expansion of the amalgam
over time. Many dentists would assert that there are no situations at
all, ever, which cannot be dealt with using non-mercury based alternatives.
One of the main difficulties here is that amalgams are relatively easy
to use but the alternatives are more technique sensitive and require
a higher skill level to manage correctly. This is surely a compelling
argument to increase skills through better teaching at the undergraduate
level and at the post graduate level, rather than dumbing down
to the lowest common denominator.
Dr. Harold Loe, the Director of
the National Institute of Dental Research (NIDR), wrote in the September,
1993 edition of "Dental Products Report":
"That first filling is a critical step in the life of a tooth.
Using amalgam for the first filling requires removing a lot of the tooth
substance, not only diseased tooth substance but healthy tooth substance
as well. So, in making the undercut you sacrifice a lot, and this results
in a weakened tooth. The next thing you know the tooth breaks off, and
you need a crown. Then you need to repair the crown...and so it continues
to the stage where there is no more to repair and you pull the tooth.
With the first filling you should do something that can either restore
the tooth or retain more healthy tooth substance. Use new materials-composites
or materials you can bond to the surface without undercuts. You can
do this with little removal of the tooth substance so that the core
of the tooth is still there."
In 1995 the editor-in-chief of Quintessence (Volume 26, Number
3,1995), Dr Richard Simonsen wrote:
Amalgam should never be used
as a restorative material in paediatric dentistry.
Amalgam should never be used
as a first time restorative material.
Why?
Because better alternatives
are available. Move Over Amalgam - At Last
Another fact is that research has clearly shown that when amalgams
are placed in teeth as fillings, then within a relatively short time,
weeks not months, mercury which was present in the amalgam can be detected
in virtually every other part of the body Ð brain, kidney, lungs, heart,
etc. [lxxii] , [lxxiii]
It has been conceded in dental articles that if amalgam was introduced
today, as a new material, it would have no hope at all of passing safety
requirements and as such would have no hope of being introduced onto
the market due to the high levels of mercury released. The only reason
amalgam is still available is that it was grandfathered in and not subject
to the same health standards as newer materials. With today's knowledge
how can this situation still be acceptable?
Alternatives to amalgam have
been around for a long time.
Why is the NHMRC still endorsing
its use today? |
| |
Go to top of page |
Glossary |
ADA |
Australian
Dental Association |
AmDA |
American Dental
Association |
ASOMAT |
Australasian
Society of Oral Medicine and Toxicology |
ATSDR |
Agency for
Toxic Substances and Disease Registry. It is a branch of the United
States Environmental Protection Agency |
FDA |
Food and Drug
Administration (USA) |
mcg Hg/m3 |
micrograms
of mercury vapour per cubic meter |
Micromercurialism |
long-term,
low-level mercury poisoning. As from dental amalgam |
Mercury Organic |
mercury atom
combined with other atoms to form an organic compound |
Mercury Inorganic |
this is the
same as elemental mercury. It is the metallic form |
MSDS |
Material Safety
Data Sheet |
MRL |
Maximum Recommended
Level |
NHMRC |
National Health
& Medical Research Council |
NOEL |
|
No Observable
Effects Level |
paediatric
dentistry |
|
|
Dentistry for
children |
TDI |
Tolerable Daily
Intake |
WHO |
World Health
Organization |
USEPA |
United States
Environmental Protection Agency |
|
|
|
|
|
|
References:
[i] Mercury Usage in Canadian Dentistry Dr. Murray J. Vimy Clinical Associate Professor, Faculty of Medicine, University
of Calgary Position paper for submission to Health Canada
[ii] Pendergrass JC et al Neurotoxicology
june-july 1997
[iii] Assessment Of Mercury Exposure And Risks From Dental Amalgam G. Mark Richardson
PhD., Medical Devices Bureau, Environmental Health Directorate, Health
Canada December 1995
[iv] Bio-Probe Newsletter
Vol 11 March 1995 Issue 2
[v] Wieliczka DM Spencer P Moffitt
CE Wagner EJ Wandera A Equilibrium vapour pressure of mercury
from dental amalgam in vitro.Dent Mater (1996 May) 12(3):179-84
[vi] Bjorkman L; Lind B Factors influencing
mercury evapouration rate from dental amalgam fillings. Scand
J Dent Res, 100: 6, 1992 Dec, 354-60
[vii] Lussi, A Mercury Release From Amalgam
Into Saliva: An In-Vitro Study.. Schweiz Monatsschr Zahnmed, 103(6):722-6,
1993.
[viii] Olsson, S; Bergman, M.: Daily Dose Calculations
from Measurements of Intra-oral Mercury Vapour. J Dent Res. 71(2):414-23.
Feb 1992.
[ix] Emler and Cardone, "An assessment
of mercury in mouth air", Oral Roberts University, March 1985
[x] Vimy MJ Lorscheider FL Serial measurements
of intra-oral air mercury: estimation of daily dose from dental amalgam :
J Dent Res (1985 Aug) 64(8): 1072-5
[xi] Abraham J, Svare C , Frank C,. The
effects of dental amalgam restorations on blood mercury levels. J. Dent. Res.
63(1):71 73,1984
[xii] Ott K et. al. Mercury burden due to amalgam
fillings. Dtsch. Zahnarztl Z
39(9):199-205, 1984
[xiii] SvareCW et.al. The effects of dental
amalgam on mercury levels in expired air. J. Dent. Res.60(9):1668-1671,1981
[xiv] Vimy M.J., and Lorscheider F.L. Intra-oral
mercury released from dental amalgam, Journal of Dental Research , Vol 64:1069-1071,
1985,
[xv] Serial meaurements of intra-oral air mercury
and the estimation of daily dose from dental amalgam. Journal of Dental Research
Vol 64:1072-1075, 1985.
[xvi] Sato,
K; Kusada, Y; Zhangihiro, H; Ishii, Y; Mori, T; Hirai, T; Yomiyama, T; Iida,
K. An Epidemiological Study of Mercury Sensitization. Allergology International,
46:201‑6, 1997.
[xvii] Brun.R., Epidemiology
of contact dermatitis in Geneva Contact Dermatitis
1:214‑217 1975
[xviii] Djerrasi.E.,
Berova.N., The possibilities of allergic reactions from
Silver Amalgam restorations
Int Dent J
19:4 481‑488 1969
[xix] Nebenfuher.L.,
et al. Mercury Allergy in Budapest Contact Dermatitis 10(2)
: 121‑122 1983
[xx] Rudner
et al. Epidemiology of contact dermatitis in Nth. America Arch
Derm 108 (4) 537‑40 1973 1997.
[xxi] White.R.,
Brandt.R., Development of mercury hypersensitivity among dental students.
JADA
92: 1204‑1207 1976
[xxii] Hultman Adverse immunological effects
and autoimmunity induced by dental amalgam and alloy in mice.
: FASEB J (1994 Nov) 8(14):1183-90
[xxiii] Hultman: Murine mercury-induced immune-complex
disease: effect of cyclophosphamide treatment and importance of T-cells.
Br J Exp Pathol (1989 Jun) 70(3):227-36
[xxiv] J. Can.. Dent 1994 Special Report
[xxv] Nylander et al.Fourth international symposium
Epidemiology in Occupational Health.,Como Italy Sept 1985
[xxvi] Gonzalez-Ramirez, D. Et al. Urinary
mercury, porphyrins and neurobehavioral changes in dental workers in Monterrey,
Mexico. J Pharmacol Exp Therap. 272:264-274,1995
[xxvii] Echeverria, D; Heyer, NJ; Martin, MD;
Naleway, CA; Woods, JS; Bittner AC,
Jr.
Behavioral Effects of Low-Level Exposure to Hg¡ among Dentists.
Neurotoxicology
and Teratology. 17(2):161-168, 1995.
[xxviii] Shapiro, IM; et al. Neurophysiological
and neuroDsvchological function in
mercury
exposed dentists. Lancet, 1(8282):1147-1150, 1982
[xxix] Gordon HP, Cordon LD: reduction in mercury
vapour levels in Seattle dental offices. J Dent Res Abstract 1092 57A:347,
1981.
[xxx] Sikorski R et al .Women in dental
surgeries: reproductive hazards in occupational exposure to metallic mercury.
Int Arch Occup Environ Health (1987) 59(6):551-7
[xxxi] EPA Mercury Health Effects update
Health Issue Assessment. 1984 EOA-600/8-84f. USEPA
[xxxii] Lorscheider FL, Vimy MJ, Summers AO, Zwiers
H. The dental amalgam mercury controversy--inorganic mercury and the CNS;
genetic linkage of mercury and antibiotic resistances in intestinal bacteria.
Toxicology. 1995 Mar 31;97(1-3):19-22.
[xxxiii] Methylation of mercury from dental amalgam
and mercuric chloride by oral Streptococci Heintz, Edwardson,
Derand, Birkhed Scan. J. Dent. Res. 1983,
91:150-152
[xxxiv] The Methylation of Mercuric Chloride by
Human Intestinal Bacteria Rowland, Grasso, Davies Experiential.
Basel 1975 ,31: 1064-1065
[xxxv] Dental Amalgam Fillings and the Amount of Organic
Mercury in Human Saliva. Leistevuo, J; Leistevuo, T: Helenius, H, Pyy,
L; Osterblad, M; Huovinen, P; Tenovuo, J. Caries Res., 35(3):163‑6,
May‑Jun 2001
[xxxvi] Health risks from exposure to mercury
from crematoria. The Institute of Environmental Medicine, Karolinska Institute
Report, 51M 1/92. More mercury from crematoria : Nature 1990 Aug 16;346(6285):615.
Comment on: Nature 1990 Oct 18;347(6294):623 Nature. 1991 Feb 28; 349(6312
): 746-
[xxxvii] Reese Km. Mercury emissions from
crematoria. Chem & Engin News,
12-7-98, p80-81; & Lancet 1998; 352, 1602.
[xxxviii] Mercury emission measurements in a crematorium.
The dentistry aspects . Schweiz Monatsschr Zahnmed 1995;105(8):1023-8
[xxxix] Mercury in Saliva and the Risk of Exceeding Limits
for Sewage in Relation to Exposure to Amalgam Fillings. Leistevuo, J;
Leistevuo, T: Helenius, H; Pyy, L; Huovinen, P; Tenovuo, J. Arch Environ Health,
57(4):366‑70, Jul‑Aug 2002.
[xl] G.Drasch et al, Mercury Burden of Human
Fetal and Infant Tissues, Eur J Pediatr 153:607-610,1994;
[xli] E.Lutz et al, Concentrations of
mercury in brain and kidney of fetuses and infants, Journal of Trace Elements
in Medicine and Biology, 1996,10:61-67;
[xlii] Vimy MJ Takahashi Y Lorscheider
FL Am J Physiol (1990 Apr) 258(4 Pt 2):R939-45
[xliii] Drasch et. al. J Trace Elements
in Medicine and Biology; 9(2):82-7, 1995
[xliv] Verchaeve L et al., Comparative in vitro cytogenetic studies in mercury exposed
human lymphocytes Mutation Res., 1985:157;221-226
[xlv] PelletierL et al., In - vivo self reactivity of mononuclear cells to T cells
and macrophages exposed to HgCl2 Eur. J Immune., 1985: 460-465
[xlvi] Veron et al Amalgam Dentaires et allergies J Biol Buccale., 1986 : 14; 83-100
[xlvii] NouyeM., Murao K., Kajiwara Y., Behavorial and neuropathological effects of
prenatal methyl mercury exposure in mice..
Neurobeahv.Toxicol Teratol. ,1985:7;227-232
[xlviii] Khera et al., Teratogenic and genetic effects of mercury toxicity. The biochemistry
of Mercury in the environment. Nriagu,
J.O.Ed Amsterdam Elsevier, 503-18,1979
[xlix] Hansen K et al A survey of metal induced mutagenicity in vitro and in vivo J
Amer Coll Toxicol ., 1984:3;381-430
[l] Koos, B.J. and Longo, L.D.: Mercury Toxicity in the Pregnant Woman, Fetus and
Newborn Infant. Am. J. Obstet. Gynecol. 12d, 390, 1970.
[li] Takahashi, Y; Tsuruta, S; Hasegawa, J; Kameyama, Y.: Number of Amalgam Fillings
in Pregnant Rats and Mercury Concentration in Their Fetuses. J Dent Res. 71(SI):571.
A-445. 1992.
[lii] Placental Transfer of Mercury in Pregnant Rats Which
Received Dental Amalgam Restorations. Takahashi, Y; Tsuruta, S; Arimoto,
M; Tanaka, H; Yoshida, M. Toxicology, 185(1‑2):23‑33, Mar 2002.
[liii] Placental to Fetal Transfer of Mercury and Fetotoxicity. Yoshida, M. Tohoku J Exp Med, 196(2):79‑88, Feb 2002.
[liv] Drasch G, Aigner S, Roider
G, Staiger F, Lipowsky G Mercury in human colostrum
and early breast milk. Its dependence on dental amalgam and other
factors. J Trace Elem Med Biol (1998 Mar Mar) 12(1):23-7
[lvi] BOYD, N. D., H. BENEDIKTSSON, M. J. VIMY,
D. E. HOOPER,AND F. L. LORSCHEIDER. Mercury from dental "silver"
tooth fillings impairs sheep kidney function. Am. J. Physiol. 261 (Regulatory
Integrative Comp. Physiol. 30): RlOlO- R1014, 1991.-
[lvii] Rowland AS et al The effect of occupational exposure to mercury vapour
on the fertility of female dental assistants Occup
Environ Med (1994 Jan) 51(1):28-34
[lviii] Sikorski R et al .Women in dental surgeries: reproductive hazards in occupational
exposure to metallic mercury. Int Arch Occup Environ Health (1987)
59(6):551-7
[lix] Gordon HP, Cordon LD: reduction in mercury vapour levels in Seattle dental offices.
J Dent Res Abstract 1092 57A:347, 1981
[lx] Can.. Dent 1994 Special Report
[lxi] Nylander et al.Fourth international symposium Epidemiology in Occupational
Health.,Como Italy Sept 1985
[lxii] Christopher C. W. Leong*, Naweed I. Syed ,
Fritz L. Lorscheiderà Retrograde degeneration of neurite membrane structural
integrity of nerve growth cones following in vitro exposure to mercury NeuroReport
VOLUME: 12 ISSUE: 04 PAGES: 0733-0737
[lxiii] Cognitive Deficit in 7-Year-Old Children
With Prenatal Exposure to Methylmercury. Grandjean, P; Weihe, P; White, RF;
Debes, F; Araki, S; Yokoyama, I; Murata, K; Sorensen, N; Dahl, R; Jorgensen,
PJ. Neurotoxicol Teratol., 19(6):417-28, Nov-Dec 1997
[lxiv] It has been well documented and referenced
that classic signs of chronic mercury exposure include gingivitis, alveolar
bone loss, loosening and loss of teeth, bruxism, metallic taste, oral ulceration,
and excessive salivation. (Shafer, W.G.; Hine, M.K.; and Levy, B.M. 1958.
[lxv] Hultman P et al. Adverse immunological
effects and autoimmunity induced by dental amalgam and alloy in mice.
FASEB J (1994 Nov) 8(14): 1183-90
[lxvi] V.D.M.Stejskal, Dept. Of Clinical
Chemistry, Karolinska Institute, Stockholm, Sweden
[lxvii] Adverse immunological effects and autoimmunity induced by dental amalgam
and alloy in mice. Hultman: FASEB J (1994 Nov) 8(14):1183-90
[lxviii] Murine susceptibility to mercury. II. autoantibody profiles and renal
immune deposits in hybrid, backcross, and H-2d congenic mice. Hultman: Clin
Immunol Immunopathol (1993 Jul) 68(1):9-20
[lxix] Kosuda LL Greiner DL Bigazzi PE Mercury-induced renal autoimmunity
in BN-->LEW.1N chimeric rats. Cell Immunol (1994 Apr 15) 155(1):77-94
[lxx] Omura Y Shimotsuura Y Fukuoka
A Fukuoka H Nomoto T Significant mercury deposits in internal
organs following the removal of dental amalgam, & development
of pre-cancer on the gingiva and the sides of the tongue and their represented
organs as a result of inadvertent exposure to strong curing light (used
to solidify synthetic dental filling material) & effective
treatment: a clinical case report, along with organ representation areas for
each tooth.
In:
Acupunct Electrother Res (1996 Apr-Jun) 21(2):133-60
[lxxi] ATSDR. Toxicological Profile for Mercury. U.S. Department
of Health & Human Services, 1999.
[lxxii] Hahn LJ Kloiber R Leininger
RW Vimy MJ Lorscheider FL. FASEB J (1990 Nov) 4(14):3256-60
[lxxiii] Vimy MJ Takahashi Y Lorscheider
FL Am J Physiol (1990 Apr) 258(4 Pt 2):R939-45
|
|