| This is a transcript of a lecture delivered to the
Proceedings of the First World Congress on Cancer by Professor W Kostler
(President of Austrian Society of Oncology, Austria.)
Sydney 1984
Professor W Kostler
Glutadione Peroxidase and Selenium
The glutadione peroxidase is detoxifying peroxides to water and
glutadione. We try to improve the scavenging activity by applying
selenium. There is a correlation between the level of glutadione
peroxidases in the blood and the plasma selenium. A study was made
in the US, on AIDS patients and patients with AIDS related complexes,
using a control group. A direct correlation was found between the
plasma selenium level and glutadione peroxidase activity in the
blood. It is very important to supply this selenium, because glutadione
peroxidase is one of the most effective scavengers.
Excessive intake of selenium (2,000 to 5,000 micrograms a day)
is said to produce poisoning. But it is not true in a way - we know
that women m Venezuela take 5,000 micrograms a day and don't suffer
from breast cancer. The optimal intake is in comparison to the sub-optimal
intake- sub-optimal means 50 to 200 micrograms a day and optimal
intake is 250 to 300 per day. Optimal means you have some reserve,
for example, for radiotherapy or chemotherapy, with agents that
activate radicals in your body.
The normal level of selenium should be 80 to 130 micrograms per
litre of blood. We check the levels of selenium in different cancer
patients at their first consultation in our office - most of them
suffer from a big deficiency in selenium. One patient had a level
of 49 micrograms-a very low level in a person with advanced bladder
cancer.
Effects of Mercury in Dental Amalgam
1 want to emphasise that there is a very strong interaction between
some trace elements, and I'll focus on mercury and selenium. A surplus
of mercury causes a diminution of selenium. Why is that important?
Most of our cancer patients have a lot of amalgam dental fillings.
1 remember a study we made few years ago at the University of Vienna.
One group of students with amalgam fillings had to chew a chewing
gum for twenty minutes, and the other group had to drink hot lemon
juice for twenty minutes. We wanted to know what happens with the
mercury level in their blood. By chewing the gum, with dental fillings
of amalgam, or by drinking hot and acid juices, there was always
a big mercury intake in the blood.
In the same way, the level of selenium was lowered, because a lot
of selenium was needed to detoxify the mercury to mercury Selenite,
and therefore it was not available any longer. What we didn't expect
was that the immune status showed us a small decrease in the immune-competent
cells after this test-after 20 minutes of chewing gum or drinking
hot juice
Therefore, we usually try to remove the dental fillings made out
of amalgam, and use chelation therapy to bring out the mercury,
leaving the selenium free for the glutadione peroxidase activity
again. Such a patient can have normal mercury levels in the blood,
but after the injection DMPS there is a large amount of mercury
over the next 24 hours, going out with the urine. The mercury is
deposited in the brain and the central nervous system, mostly in
the hypophysis, and causes a lot of problems with hormonal regulation. |